Establishment of left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Establishment of left/right asymmetry pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM216A, MLYCD, and RPS19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM216A grouped by Establishment of left/right asymmetry-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAM216A →	-0.164	-0.129	.003	.002	3	4
OESOPHAGUS	MLYCD →	+0.181	+0.113	.002	.002	3	4
LUNG_NSCLC_LUSC	RPS19 →	-0.258	-0.079	.006	.007	3	4
LUNG_SCLC	ZNF672 →	-0.142	-0.120	.005	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF534 →	+0.221	+0.133	.008	.001	3	4
BREAST	EPHB6 →	+0.155	+0.739	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM216A by Establishment of left/right asymmetry activity — STOMACH

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