Midbody abscission

Across TCGA patient cohorts, RNA activity of the Midbody abscission pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM10, CDC6, and ANLN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbody abscission activity versus MCM10 in UCEC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCM10 →	+0.899	+0.205	.002	.008	3	5
UCEC	CDC6 →	+0.737	+0.177	.001	.003	3	5
BRCA	ANLN →	+0.875	+0.180	<.001	<.001	3	4
BRCA	CEP55 →	+0.893	+0.173	<.001	<.001	3	4
BRCA	CDC25A →	+0.813	+0.231	<.001	<.001	3	4
BRCA	CKAP2L →	+0.922	+0.199	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061952 vs MCM10 — UCEC

Explore this scatter interactively →