Midbody abscission

Across TCGA cell cohorts, RNA activity of the Midbody abscission pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM120AOS, NDUFA5, and SMPD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbody abscission activity versus FAM120AOS in BREAST (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM120AOS →	+1.021	+0.814	.004	.008	3	5
STOMACH	NDUFA5 →	+0.739	+1.008	.004	.007	3	5
STOMACH	SMPD2 →	+0.881	+1.325	.003	.005	2	6
OESOPHAGUS	PNRC2 →	+0.629	+0.951	.002	.008	3	5
URINARY_TRACT	LYRM2 →	+0.814	+2.179	.006	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	THTPA →	+1.068	+1.871	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061952 vs FAM120AOS — BREAST

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