Regulation of protein K48-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein K48-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCOR1, SYNGAP1, and PRSS12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCOR1 grouped by Regulation of protein K48-linked ubiquitination-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RCOR1 →	+1.149	+1.881	<.001	<.001	3	6
BLOOD_Myeloma	SYNGAP1 →	+1.300	+1.659	<.001	.003	3	4
BONE	PRSS12 →	-2.266	-1.979	<.001	<.001	3	4
CNS	ZNF816 →	-0.706	-1.169	<.001	<.001	3	4
KIDNEY	THSD1 →	-1.178	-1.036	.003	<.001	3	4
BONE	PPM1H →	-1.674	-1.700	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCOR1 by Regulation of protein K48-linked ubiquitination activity — BONE

Explore this box plot interactively →