Regulation of protein K48-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein K48-linked ubiquitination pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSSK1B, PRKCZ, and HRH4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSSK1B grouped by Regulation of protein K48-linked ubiquitination-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TSSK1B →	+0.138	+0.109	<.001	<.001	3	5
OVARY	PRKCZ →	-0.166	-0.119	.007	.002	3	5
SOFT_TISSUE	HRH4 →	+0.178	+0.151	.008	<.001	3	5
STOMACH	ACLY →	-0.320	-0.130	.004	.001	3	5
BLOOD_Myeloma	RPL36AL →	+0.156	+0.153	.005	.006	3	5
STOMACH	DIRAS3 →	-0.236	-0.179	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSSK1B by Regulation of protein K48-linked ubiquitination activity — BREAST

Explore this box plot interactively →