Regulation of protein K48-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein K48-linked ubiquitination pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GW441756, NSC-207895, and Capivasertib, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GW441756 grouped by Regulation of protein K48-linked ubiquitination-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GW441756 →	+0.400	+0.082	.025	.041	3	2
KIDNEY	NSC-207895 →	+1.131	+0.174	.020	.021	2	3
SKIN	Capivasertib →	-0.875	-0.123	.041	.041	2	3
CNS	Ulixertinib →	-1.429	-0.083	.008	.042	3	2
CNS	TL-1-85 →	-0.465	-0.082	.005	.041	3	2
CNS	CAP-232 →	+1.319	+0.091	.006	.026	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GW441756 by Regulation of protein K48-linked ubiquitination activity — CNS

Explore this box plot interactively →