Autophagosome-lysosome fusion

Across TCGA patient cohorts, RNA activity of the Autophagosome-lysosome fusion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1625, KMT2A, and NPEPPS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome-lysosome fusion activity versus MAP1B_S1625 in LSCC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S1625 →	+0.853	+0.074	.001	<.001	3	5
LUAD	KMT2A →	-0.140	-0.034	<.001	.001	3	4
HNSC	NPEPPS →	+0.221	+0.063	<.001	.009	3	4
OV	UBLCP1 →	+0.226	+0.053	.001	.002	3	4
OV	POLG →	-0.251	-0.063	<.001	<.001	3	4
UCEC	HSPA13 →	-0.263	-0.074	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061909 vs MAP1B_S1625 — LSCC

Explore this scatter interactively →