Autophagosome-lysosome fusion

Across TCGA patient cohorts, RNA activity of the Autophagosome-lysosome fusion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BEND3, KCNK6, and CEP76, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome-lysosome fusion activity versus BEND3 in LSCC (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BEND3 →	-0.589	-0.323	<.001	<.001	3	5
BRCA	KCNK6 →	+0.654	+0.085	.004	<.001	3	5
LSCC	CEP76 →	-0.412	-0.172	<.001	.002	3	5
LSCC	PA2G4 →	-0.659	-0.339	<.001	<.001	3	5
LSCC	CD69 →	+0.681	+0.186	<.001	.001	3	4
LSCC	CSE1L →	-0.508	-0.231	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061909 vs BEND3 — LSCC

Explore this scatter interactively →