Autophagosome-lysosome fusion

Across TCGA cell cohorts, RNA activity of the Autophagosome-lysosome fusion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PXMP2, TSPAN2, and TMEM117, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PXMP2 grouped by Autophagosome-lysosome fusion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PXMP2 →	-0.834	-1.068	.006	.006	3	4
SKIN	TSPAN2 →	+0.742	+1.176	.001	.001	3	4
STOMACH	TMEM117 →	-1.338	-1.161	.002	.002	3	4
STOMACH	PLIN3 →	+1.448	+1.466	.006	<.001	3	4
BREAST	ITPRIP →	+1.187	+0.959	.004	.001	3	4
STOMACH	EP300 →	-1.006	-1.556	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PXMP2 by Autophagosome-lysosome fusion activity — BLOOD_Leukemia

Explore this box plot interactively →