Autophagosome-lysosome fusion

Across TCGA cell cohorts, RNA activity of the Autophagosome-lysosome fusion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF15, IRF9, and GEMIN6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome-lysosome fusion activity versus TAF15 in BREAST (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TAF15 →	-0.883	-1.017	.005	.004	3	6
PANCREAS	IRF9 →	+1.436	+1.340	.005	<.001	3	6
URINARY_TRACT	GEMIN6 →	-0.835	-1.454	.005	.002	3	6
BONE	TCF12 →	-1.237	-1.475	.004	.001	3	6
LIVER	C17orf75 →	-1.212	-1.547	.002	<.001	3	6
OVARY	GIT1 →	-0.830	-1.057	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061909 vs TAF15 — BREAST

Explore this scatter interactively →