Glial cell activation

Across TCGA patient cohorts, RNA activity of the Glial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5AR1, LILRA6, and SIGLEC9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell activation activity versus C5AR1 in GBM (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C5AR1 →	+1.441	+0.324	<.001	.005	3	10
GBM	LILRA6 →	+1.335	+0.375	<.001	<.001	3	10
LSCC	SIGLEC9 →	+0.569	+0.185	<.001	<.001	3	9
COAD	LILRB2 →	+0.706	+0.167	.003	.002	2	10
BRCA	HK3 →	+1.001	+0.339	<.001	.006	3	9
PDAC	FPR2 →	+1.305	+0.239	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061900 vs C5AR1 — GBM

Explore this scatter interactively →