Glial cell activation

Across TCGA cell cohorts, RNA activity of the Glial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAGD, IFNAR2, and F3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRAGD grouped by Glial cell activation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RRAGD →	+2.220	+0.283	.001	.004	3	4
URINARY_TRACT	IFNAR2 →	+1.734	+1.924	<.001	<.001	3	4
CNS	F3 →	-3.354	-1.077	.002	<.001	3	4
STOMACH	PLEKHB1 →	+3.284	+0.328	<.001	<.001	3	4
SOFT_TISSUE	FCGRT →	+2.748	+0.313	.008	.007	3	3
SOFT_TISSUE	ARMCX1 →	+2.740	+0.294	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRAGD by Glial cell activation activity — SOFT_TISSUE

Explore this box plot interactively →