Glial cell activation

Across TCGA cell cohorts, RNA activity of the Glial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNGR1, DNAJC9, and WDR62, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell activation activity versus IFNGR1 in LIVER (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IFNGR1 →	+1.186	+0.140	<.001	.001	3	14
BREAST	DNAJC9 →	-0.957	-0.190	<.001	<.001	3	12
BREAST	WDR62 →	-1.481	-0.172	<.001	<.001	3	12
BREAST	DNA2 →	-1.044	-0.188	<.001	<.001	3	12
LUNG_NSCLC_LUSC	MALSU1 →	-0.684	-0.195	.002	<.001	3	12
SOFT_TISSUE	DBF4B →	-1.129	-0.133	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061900 vs IFNGR1 — LIVER

Explore this scatter interactively →