Glial cell activation

Across TCGA cell cohorts, RNA activity of the Glial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAZ3, TMBIM4, and SLC1A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell activation activity versus OAZ3 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OAZ3 →	+0.792	+1.004	.009	.003	3	4
BLOOD_Leukemia	TMBIM4 →	+0.765	+1.001	<.001	<.001	3	4
BREAST	SLC1A4 →	+1.836	+1.137	<.001	.001	3	4
BREAST	PIAS3 →	+0.955	+1.385	.004	.001	3	4
BLOOD_Myeloma	SLC18B1 →	-1.833	-1.172	.001	.007	2	5
KIDNEY	PAOX →	-0.559	-0.430	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061900 vs OAZ3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →