Negative regulation of astrocyte activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of astrocyte activation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEA1_S52, AHNAK_S5749, and RABGAP1_S56, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of astrocyte activation activity versus EEA1_S52 in BRCA (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EEA1_S52 →	+0.680	+0.073	<.001	<.001	3	6
PDAC	AHNAK_S5749 →	+0.945	+0.105	<.001	.005	3	4
BRCA	RABGAP1_S56 →	+0.714	+0.061	<.001	.003	3	4
LSCC	BICD2 →	+0.355	+0.073	<.001	.002	3	4
CCRCC	JUNB →	+0.339	+0.063	<.001	<.001	3	4
GBM	CA12 →	+0.806	+0.067	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061889 vs EEA1_S52 — BRCA

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