Negative regulation of astrocyte activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of astrocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LLGL2, ARRB2, and RPL10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LLGL2 grouped by Negative regulation of astrocyte activation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LLGL2 →	+1.347	+1.222	.005	<.001	3	5
BONE	ARRB2 →	+1.374	+1.698	.005	.003	3	4
BLOOD_Myeloma	RPL10 →	-1.002	-1.779	<.001	<.001	3	4
OESOPHAGUS	MSL3 →	-0.509	-0.814	.006	.004	3	4
BONE	TBL1X →	-0.689	-2.126	.005	<.001	3	4
URINARY_TRACT	RHOV →	+3.143	+1.482	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LLGL2 by Negative regulation of astrocyte activation activity — CNS

Explore this box plot interactively →