Regulation of astrocyte activation

Across TCGA patient cohorts, RNA activity of the Regulation of astrocyte activation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FGA, FGB, and MMP9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of astrocyte activation activity versus FGA in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FGA →	+0.437	+0.116	<.001	<.001	3	5
OV	FGB →	+0.754	+0.079	.009	.006	3	5
LUAD	MMP9 →	+0.606	+0.080	.005	.006	3	5
COAD	S100A12 →	+0.942	+0.048	<.001	.006	2	6
COAD	STOM →	+0.312	+0.058	.005	.002	3	5
HNSC	PADI4 →	+0.528	+0.079	.002	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061888 vs FGA — LSCC

Explore this scatter interactively →