Regulation of astrocyte activation

Across TCGA cell cohorts, RNA activity of the Regulation of astrocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGBL5, DMKN, and DYNC2LI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGBL5 grouped by Regulation of astrocyte activation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AGBL5 →	+0.545	+0.989	.003	.006	2	5
LUNG_SCLC	DMKN →	+2.495	+0.770	.004	.007	3	4
KIDNEY	DYNC2LI1 →	+1.272	+1.318	<.001	.003	2	4
KIDNEY	SLAIN1 →	+1.618	+1.296	<.001	.002	3	3
KIDNEY	EPS8 →	+1.683	+1.440	.004	<.001	3	3
KIDNEY	CCDC148 →	+1.029	+1.132	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGBL5 by Regulation of astrocyte activation activity — OVARY

Explore this box plot interactively →