Regulation of astrocyte activation

Across TCGA cell cohorts, RNA activity of the Regulation of astrocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDLR, IL6, and IL15RA, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of astrocyte activation activity versus LDLR in SKIN (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LDLR →	+2.073	+0.589	<.001	<.001	3	16
KIDNEY	IL6 →	+3.227	+0.345	<.001	.004	3	7
SOFT_TISSUE	IL15RA →	+1.446	+0.231	.003	<.001	3	7
LIVER	IRAK2 →	+1.708	+0.179	.002	.005	3	7
SOFT_TISSUE	FNDC3B →	+0.997	+0.219	<.001	.002	3	6
OVARY	CDCP1 →	+1.574	+0.180	.008	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061888 vs LDLR — SKIN

Explore this scatter interactively →