Antimicrobial humoral immune response mediated by antimicrobial peptide

Across TCGA patient cohorts, RNA activity of the Antimicrobial humoral immune response mediated by antimicrobial peptide pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OAS2, SAMD9, and PARP14, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antimicrobial humoral immune response mediated by antimicrobial peptide activity versus OAS2 in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	OAS2 →	+0.710	+0.077	<.001	<.001	3	10
HNSC	SAMD9 →	+0.743	+0.125	<.001	<.001	3	9
HNSC	PARP14 →	+0.465	+0.106	<.001	<.001	3	9
CCRCC	FMNL1 →	+0.442	+0.099	<.001	<.001	3	9
BRCA	GBP4 →	+0.642	+0.064	<.001	<.001	3	9
HNSC	STAT1 →	+0.699	+0.136	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061844 vs OAS2 — LSCC

Explore this scatter interactively →