Antimicrobial humoral immune response mediated by antimicrobial peptide

Across TCGA patient cohorts, RNA activity of the Antimicrobial humoral immune response mediated by antimicrobial peptide pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A12, S100A8, and NDRG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antimicrobial humoral immune response mediated by antimicrobial peptide activity versus S100A12 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	S100A12 →	+1.651	+0.194	<.001	<.001	3	8
BRCA	S100A8 →	+2.757	+0.339	<.001	<.001	3	7
GBM	NDRG1 →	+1.352	+0.340	<.001	<.001	3	6
GBM	AQP9 →	+1.102	+0.229	<.001	<.001	3	6
UCEC	PI3 →	+3.314	+0.302	<.001	<.001	3	6
GBM	LIF →	+1.807	+0.319	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061844 vs S100A12 — HNSC

Explore this scatter interactively →