Antimicrobial humoral immune response mediated by antimicrobial peptide

Across TCGA cell cohorts, RNA activity of the Antimicrobial humoral immune response mediated by antimicrobial peptide pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C8G, MOB3B, and ABLIM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C8G grouped by Antimicrobial humoral immune response mediated by antimicrobial peptide-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C8G →	-0.483	-0.774	.001	.001	3	4
OVARY	MOB3B →	-1.641	-0.853	<.001	.009	3	4
OVARY	ABLIM1 →	-2.931	-0.910	<.001	.005	3	4
BLOOD_Leukemia	CTSA →	-1.067	-1.065	.007	.003	3	4
PANCREAS	MAP3K1 →	-1.256	-1.030	<.001	.002	3	4
SKIN	AKR1D1 →	-0.039	-0.688	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C8G by Antimicrobial humoral immune response mediated by antimicrobial peptide activity — SKIN

Explore this box plot interactively →