Antimicrobial humoral immune response mediated by antimicrobial peptide

Across TCGA cell cohorts, RNA activity of the Antimicrobial humoral immune response mediated by antimicrobial peptide pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS3, KLF5, and ZKSCAN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antimicrobial humoral immune response mediated by antimicrobial peptide activity versus LGALS3 in CNS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LGALS3 →	+2.954	+0.296	.001	<.001	3	6
LARGE_INTESTINE	KLF5 →	+1.683	+0.132	.004	.005	3	5
BLOOD_Lymphoma	ZKSCAN4 →	-0.739	-0.156	.001	.003	3	5
LUNG_SCLC	ZNF439 →	-1.493	-0.146	.003	.006	3	5
KIDNEY	ZNF776 →	-1.050	-0.326	<.001	.003	3	4
KIDNEY	DCAF16 →	-0.868	-0.230	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061844 vs LGALS3 — CNS

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