Telomeric D-loop disassembly

Across TCGA patient cohorts, RNA activity of the Telomeric D-loop disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRX1, CARD6, and RAD51AP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomeric D-loop disassembly activity versus PRRX1 in BRCA (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRRX1 →	-0.757	-0.146	<.001	.007	3	5
OV	CARD6 →	-0.733	-0.341	.001	<.001	3	4
BRCA	RAD51AP1 →	+0.752	+0.229	<.001	.001	3	4
LSCC	NCAPH →	+0.527	+0.155	<.001	.001	3	4
LSCC	SGO1 →	+0.708	+0.245	<.001	<.001	3	4
BRCA	DKC1 →	+0.533	+0.263	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061820 vs PRRX1 — BRCA

Explore this scatter interactively →