Telomeric D-loop disassembly

Across TCGA cell cohorts, RNA activity of the Telomeric D-loop disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED7, RUNX2, and NOP16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMED7 grouped by Telomeric D-loop disassembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TMED7 →	+0.786	+1.744	<.001	<.001	3	5
BLOOD_Myeloma	RUNX2 →	+3.502	+1.966	.001	<.001	3	4
LUNG_NSCLC_LUSC	NOP16 →	-1.160	-1.254	.003	.006	3	4
STOMACH	SCMH1 →	-1.853	-1.502	.002	.001	3	4
URINARY_TRACT	CD24 →	+4.342	+1.615	.006	.006	3	4
SOFT_TISSUE	TRIAP1 →	+0.744	+1.065	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMED7 by Telomeric D-loop disassembly activity — LIVER

Explore this box plot interactively →