Telomeric D-loop disassembly

Across TCGA cell cohorts, RNA activity of the Telomeric D-loop disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELOVL1, ARL17A, and S100A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomeric D-loop disassembly activity versus ELOVL1 in LUNG_SCLC (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ELOVL1 →	-1.548	-1.438	.001	.004	3	3
PANCREAS	ARL17A →	+1.895	+1.675	.008	<.001	2	4
LUNG_SCLC	S100A4 →	-3.598	-1.448	<.001	.003	3	3
BLOOD_Lymphoma	SRSF10 →	+0.906	+1.770	<.001	<.001	3	3
BLOOD_Leukemia	KIF4B →	+0.087	+1.315	.002	.003	3	3
BLOOD_Leukemia	LRRC37A2 →	+1.427	+1.364	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061820 vs ELOVL1 — LUNG_SCLC

Explore this scatter interactively →