Endoplasmic reticulum-plasma membrane tethering

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum-plasma membrane tethering pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VAPB, RAE1, and OPA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum-plasma membrane tethering activity versus VAPB in BRCA (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VAPB →	+0.450	+0.073	<.001	<.001	3	7
LSCC	RAE1 →	+0.256	+0.062	<.001	<.001	3	6
UCEC	OPA1 →	+0.175	+0.068	.008	.003	3	5
BRCA	OSBPL2 →	+0.193	+0.053	<.001	<.001	3	5
OV	RASA2 →	-0.269	-0.066	.002	.005	3	5
CCRCC	HLA-F →	-0.518	-0.047	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061817 vs VAPB — BRCA

Explore this scatter interactively →