Endoplasmic reticulum-plasma membrane tethering

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum-plasma membrane tethering pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF189, TBC1D4, and RFTN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum-plasma membrane tethering activity versus ZNF189 in LUAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZNF189 →	-0.356	-0.293	<.001	.003	3	4
UCEC	TBC1D4 →	-0.727	-0.593	.002	.007	3	4
PDAC	RFTN2 →	-0.386	-0.843	.002	.002	3	4
LUAD	MIR4671 →	+0.576	+0.324	.008	.004	3	4
CCRCC	BCL6B →	-0.890	-0.178	<.001	<.001	3	4
CCRCC	RASGRP2 →	-0.552	-0.198	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061817 vs ZNF189 — LUAD

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