Endoplasmic reticulum-plasma membrane tethering

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum-plasma membrane tethering pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VAPB_S158, VAPA_S166, and VAPB_S160, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum-plasma membrane tethering activity versus VAPB_S158 in BRCA (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VAPB_S158 →	+0.810	+0.250	<.001	.002	3	6
PDAC	VAPA_S166 →	+0.695	+1.392	<.001	<.001	3	5
OV	VAPB_S160 →	+1.435	+0.131	<.001	<.001	3	5
UCEC	ERGIC2 →	+0.463	+0.740	<.001	.001	3	5
UCEC	ESYT1 →	+0.460	+0.807	<.001	<.001	3	5
OV	RNF5 →	+0.886	+0.107	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061817 vs VAPB_S158 — BRCA

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