Endoplasmic reticulum-plasma membrane tethering

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum-plasma membrane tethering pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESYT2, MTPN, and NUB1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum-plasma membrane tethering activity versus ESYT2 in BREAST (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ESYT2 →	+1.389	+0.166	<.001	<.001	3	16
BREAST	MTPN →	+1.014	+0.182	<.001	<.001	3	13
BREAST	NUB1 →	+0.972	+0.157	<.001	.004	3	12
BLOOD_Myeloma	RHEB →	+1.171	+0.105	.002	.007	3	12
BREAST	GNB2 →	+0.687	+0.143	.004	.001	3	12
BREAST	UBE3C →	+1.026	+0.140	.001	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061817 vs ESYT2 — BREAST

Explore this scatter interactively →