Endoplasmic reticulum-plasma membrane tethering

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum-plasma membrane tethering pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESYT2, SPAG1, and TMBIM6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum-plasma membrane tethering activity versus ESYT2 in SKIN (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ESYT2 →	+1.421	+0.287	<.001	<.001	3	8
BONE	SPAG1 →	+1.403	+0.222	.001	.002	3	7
LUNG_SCLC	TMBIM6 →	+0.749	+0.203	.001	<.001	3	7
LARGE_INTESTINE	TAF4B →	-0.950	-0.179	<.001	.001	3	7
KIDNEY	FBP1 →	+0.142	+0.185	.001	<.001	3	6
SKIN	SYTL2 →	+2.139	+0.191	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061817 vs ESYT2 — SKIN

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