Golgi lumen acidification

Across TCGA patient cohorts, RNA activity of the Golgi lumen acidification pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC9A7_S693, ZFR, and CUL4B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi lumen acidification activity versus SLC9A7_S693 in PDAC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC9A7_S693 →	+0.744	+0.047	<.001	<.001	3	4
HNSC	ZFR →	+0.275	+0.095	<.001	<.001	3	4
LUAD	CUL4B →	+0.181	+0.021	.003	.009	3	4
LUAD	MAGED2 →	+0.332	+0.026	<.001	.002	2	5
BRCA	MOCS3 →	+0.315	+0.034	<.001	.002	3	4
UCEC	PTGES →	+0.885	+0.067	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061795 vs SLC9A7_S693 — PDAC

Explore this scatter interactively →