Golgi lumen acidification

Across TCGA cell cohorts, RNA activity of the Golgi lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TERF2, COG8, and EIF4B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TERF2 grouped by Golgi lumen acidification-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TERF2 →	-0.581	-0.348	.002	.006	2	5
STOMACH	COG8 →	-0.548	-0.445	.007	<.001	3	4
BREAST	EIF4B →	-0.704	-0.296	<.001	.005	3	4
CNS	MRPL10 →	-0.454	-0.259	<.001	.001	3	4
STOMACH	NSUN4 →	-0.491	-0.330	.002	.002	3	3
BREAST	SUN3 →	+0.960	+0.298	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TERF2 by Golgi lumen acidification activity — LIVER

Explore this box plot interactively →