Golgi lumen acidification

Across TCGA cell cohorts, RNA activity of the Golgi lumen acidification pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAXBP1, ABCB10, and ZNF483, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAXBP1 grouped by Golgi lumen acidification-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PAXBP1 →	-0.489	-1.637	.009	<.001	3	5
LARGE_INTESTINE	ABCB10 →	+0.181	+1.018	<.001	.001	3	4
OESOPHAGUS	ZNF483 →	+0.154	+1.183	.006	.002	3	4
BLOOD_Leukemia	WIPI2 →	-0.273	-0.947	.007	.008	3	3
SOFT_TISSUE	PDE4D →	-0.186	-1.509	.002	.001	2	4
SOFT_TISSUE	TP53 →	-1.063	-1.655	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAXBP1 by Golgi lumen acidification activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →