Golgi lumen acidification

Across TCGA cell cohorts, RNA activity of the Golgi lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATL3, NACC2, and LYRM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi lumen acidification activity versus ATL3 in CNS (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ATL3 →	-0.686	-0.498	.004	.003	3	4
BLOOD_Leukemia	NACC2 →	+1.467	+0.726	.002	.004	3	4
CNS	LYRM1 →	-0.543	-0.612	.008	.005	3	3
CNS	CWC22 →	-0.572	-0.771	.006	.006	3	3
BONE	FIGNL1 →	+1.040	+0.268	.002	.008	3	3
BREAST	RPL30 →	-0.991	-0.786	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061795 vs ATL3 — CNS

Explore this scatter interactively →