Antifungal innate immune response

Across TCGA patient cohorts, RNA activity of the Antifungal innate immune response pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF1R, MYO1F, and ADAP2, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antifungal innate immune response activity versus CSF1R in SARC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	CSF1R →	+2.152	+0.067	<.001	<.001	3	33
SARC	MYO1F →	+1.582	+0.067	<.001	<.001	3	32
LAML	ADAP2 →	+1.938	+0.098	<.001	<.001	3	32
SARC	SPI1 →	+1.934	+0.064	<.001	<.001	3	32
SARC	CD33 →	+1.438	+0.064	<.001	<.001	3	32
LAML	CLEC4A →	+2.093	+0.117	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061760 vs CSF1R — SARC

Explore this scatter interactively →