Antifungal innate immune response

Across TCGA patient cohorts, RNA activity of the Antifungal innate immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCLS1, CYRIB, and INPP5D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antifungal innate immune response activity versus HCLS1 in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCLS1 →	+0.683	+0.123	<.001	<.001	3	8
GBM	CYRIB →	+0.270	+0.088	<.001	<.001	3	7
GBM	INPP5D →	+0.559	+0.080	<.001	<.001	3	7
GBM	TNFAIP8L2 →	+0.797	+0.140	<.001	<.001	3	7
GBM	FMNL1 →	+0.609	+0.126	<.001	<.001	3	7
GBM	PLCB2 →	+0.543	+0.107	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061760 vs HCLS1 — GBM

Explore this scatter interactively →