Antifungal innate immune response

Across TCGA cell cohorts, RNA activity of the Antifungal innate immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL10, RARRES2, and CLEC4D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL10 grouped by Antifungal innate immune response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BCL10 →	-0.275	-1.288	<.001	<.001	3	7
BREAST	RARRES2 →	-0.332	-1.280	.001	<.001	3	5
CNS	CLEC4D →	-0.334	-1.472	<.001	<.001	3	5
OVARY	PLCG2 →	-0.254	-1.353	<.001	<.001	3	4
KIDNEY	ZNF702P →	-0.153	-1.137	.002	.001	3	4
BLOOD_Myeloma	PLEKHA7 →	+0.350	+1.859	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL10 by Antifungal innate immune response activity — CNS

Explore this box plot interactively →