Antifungal innate immune response

Across TCGA cell cohorts, RNA activity of the Antifungal innate immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LARP1B, MFSD2A, and TNFSF13B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antifungal innate immune response activity versus LARP1B in BLOOD_Lymphoma (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LARP1B →	+0.790	+0.147	.001	.006	2	6
SKIN	MFSD2A →	-0.997	-0.142	.002	.003	3	4
BLOOD_Lymphoma	TNFSF13B →	+1.016	+0.142	.002	.007	3	4
BLOOD_Lymphoma	ZSWIM6 →	+1.283	+0.130	.003	.001	3	4
BLOOD_Lymphoma	PCCA →	+2.596	+0.190	.004	.001	3	4
BREAST	HMCES →	-0.890	-0.098	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061760 vs LARP1B — BLOOD_Lymphoma

Explore this scatter interactively →