Leukocyte adhesion to arterial endothelial cell

pathway activity — cross-omics
GO:0061757Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Leukocyte adhesion to arterial endothelial cell pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBAP1_S146, SRRM2_S1694, and DENR_S73, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVUBAP1_S146 →+0.447+0.060.003.00138
OVSRRM2_S1694 →-0.758-0.073.006.00237
OVDENR_S73 →-0.625-0.075.003.00137
GBMSNTB2_S222 →+0.775+0.099<.001<.00137
GBMALOX5 →+0.665+0.106<.001<.00137
GBMPLEKHO2 →+0.348+0.099<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration