Motor behavior

Across TCGA patient cohorts, RNA activity of the Motor behavior pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOP56, LIG1, and HELLS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor behavior activity versus NOP56 in BRCA (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOP56 →	-0.676	-0.425	<.001	<.001	3	3
BRCA	LIG1 →	-0.482	-0.308	<.001	.003	3	3
BRCA	HELLS →	-0.457	-0.297	<.001	<.001	3	3
BRCA	ESPL1 →	-0.951	-0.356	<.001	.004	3	3
BRCA	IL6 →	+0.759	+0.314	<.001	.001	3	3
BRCA	ADAMTS18 →	+0.724	+0.338	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061744 vs NOP56 — BRCA

Explore this scatter interactively →