Motor behavior

Across TCGA patient cohorts, RNA activity of the Motor behavior pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCARF2, NR3C1_S134, and RFC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor behavior activity versus SCARF2 in OV (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SCARF2 →	+0.820	+0.341	<.001	.002	2	4
OV	NR3C1_S134 →	+0.913	+0.463	<.001	.003	2	4
BRCA	RFC5 →	-0.308	-0.415	<.001	.001	3	3
BRCA	RPS2 →	-0.272	-0.499	<.001	<.001	3	3
COAD	MRPL15 →	-0.379	-0.778	.001	.001	3	3
BRCA	AAAS_S495 →	-1.080	-0.480	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061744 vs SCARF2 — OV

Explore this scatter interactively →