Motor behavior

Across TCGA cell cohorts, RNA activity of the Motor behavior pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTBP3, ACTR3, and RTN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTBP3 grouped by Motor behavior-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PTBP3 →	+1.270	+1.897	.006	<.001	3	4
LARGE_INTESTINE	ACTR3 →	-0.610	-0.791	.001	.003	3	3
LARGE_INTESTINE	RTN4 →	-0.549	-0.691	.009	.004	3	3
LARGE_INTESTINE	BMPR2 →	-1.034	-0.684	<.001	.001	3	3
LUNG_NSCLC_LUSC	LMO4 →	-1.513	-0.208	.001	.009	3	3
LUNG_NSCLC_LUSC	MAST4 →	+1.512	+0.220	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTBP3 by Motor behavior activity — URINARY_TRACT

Explore this box plot interactively →