Motor behavior

Across TCGA cell cohorts, RNA activity of the Motor behavior pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1A, C12orf57, and VPS54, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor behavior activity versus TUBA1A in LUNG_NSCLC_LUSC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TUBA1A →	+4.632	+0.167	<.001	<.001	3	12
BLOOD_Lymphoma	C12orf57 →	+1.652	+0.101	<.001	<.001	3	10
BLOOD_Lymphoma	VPS54 →	+1.095	+0.129	<.001	<.001	3	10
STOMACH	PRKAR1A →	+1.064	+0.154	.003	.007	3	9
STOMACH	TRPC1 →	+2.420	+0.155	<.001	<.001	3	9
OESOPHAGUS	NR3C1 →	+1.295	+0.161	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061744 vs TUBA1A — LUNG_NSCLC_LUSC

Explore this scatter interactively →