Motor learning

Across TCGA patient cohorts, RNA activity of the Motor learning pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS2, RPS5, and RRM2_S20, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor learning activity versus RPS2 in CCRCC (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPS2 →	+0.287	+0.194	<.001	<.001	3	9
COAD	RPS5 →	+0.167	+0.105	.004	<.001	3	8
BRCA	RRM2_S20 →	+0.904	+0.115	<.001	<.001	3	8
COAD	RSU1 →	-0.397	-0.113	<.001	<.001	3	8
CCRCC	TNS2 →	-0.377	-0.138	<.001	<.001	3	8
BRCA	XRCC6_T455 →	+0.488	+0.107	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061743 vs RPS2 — CCRCC

Explore this scatter interactively →