Motor learning

Across TCGA cell cohorts, RNA activity of the Motor learning pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRF, AMZ2, and ZNF595, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRF grouped by Motor learning-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTPRF →	-1.322	-1.604	.005	<.001	3	4
URINARY_TRACT	AMZ2 →	+0.417	+1.640	<.001	<.001	3	4
BLOOD_Myeloma	ZNF595 →	+4.515	+1.208	<.001	.003	3	3
BLOOD_Leukemia	TRIM16 →	+1.689	+1.576	<.001	.001	3	3
KIDNEY	NELFE →	+0.504	+1.084	.009	.009	3	3
KIDNEY	PLSCR1 →	+0.972	+0.899	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRF by Motor learning activity — OVARY

Explore this box plot interactively →