Leukotriene signaling pathway

Across TCGA cell cohorts, RNA activity of the Leukotriene signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS26A, SOX10, and MAP3K6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS26A grouped by Leukotriene signaling pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VPS26A →	+0.833	+1.210	.006	.001	3	4
SOFT_TISSUE	SOX10 →	-0.088	-1.399	<.001	.006	3	4
OVARY	MAP3K6 →	-1.102	-1.147	.002	<.001	3	4
OESOPHAGUS	EMC9 →	-1.321	-1.329	<.001	<.001	3	3
SOFT_TISSUE	SUN2 →	-0.921	-1.306	.006	.003	2	4
SOFT_TISSUE	EIF5 →	-1.002	-1.089	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS26A by Leukotriene signaling pathway activity — OESOPHAGUS

Explore this box plot interactively →