Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Across TCGA patient cohorts, RNA activity of the Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC6, FAM50A, and MOSPD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization activity versus HDAC6 in CCRCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HDAC6 →	+0.203	+0.037	.001	.001	3	6
OV	FAM50A →	+0.308	+0.071	.008	.005	3	5
COAD	MOSPD2 →	+0.334	+0.048	<.001	<.001	3	5
LSCC	GRIPAP1 →	+0.176	+0.063	<.001	<.001	3	5
UCEC	SLC26A2 →	-0.705	-0.088	.006	.002	3	4
UCEC	COX4I1 →	-0.573	-0.090	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061734 vs HDAC6 — CCRCC

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