Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Across TCGA patient cohorts, RNA activity of the Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAJ25, BHLHB9P1, and TRAJ19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization activity versus TRAJ25 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAJ25 →	+0.930	+0.160	.001	.005	3	4
HNSC	BHLHB9P1 →	+0.396	+0.246	.003	<.001	3	4
LSCC	TRAJ19 →	+0.691	+0.160	.007	.002	3	4
COAD	PDS5B →	-0.295	-0.137	<.001	.006	3	3
CCRCC	CSRNP2 →	-0.246	-0.161	<.001	.003	3	3
CCRCC	SOGA1 →	-0.655	-0.256	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061734 vs TRAJ25 — HNSC

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