Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Across TCGA patient cohorts, RNA activity of the Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZFP64, OPTN_S513, and YTHDC1_S54, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization activity versus ZFP64 in OV (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZFP64 →	-0.641	-0.291	<.001	<.001	3	4
UCEC	OPTN_S513 →	+0.575	+0.319	.002	<.001	3	4
LSCC	YTHDC1_S54 →	+0.835	+0.250	.002	<.001	3	3
BRCA	ZC3HAV1_S469 →	+0.807	+0.278	<.001	<.001	3	3
GBM	DOCK7_S946 →	-0.458	-0.186	<.001	<.001	3	3
OV	GPATCH11 →	-1.070	-0.317	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061734 vs ZFP64 — OV

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